Tiffany Scharschmidt, MD

Principal Investigator, Professor
Vice Chair of Research
Department of Dermatology

I am a dermatologist, microbiologist, and immunologist and currently serve as a Professor and the Vice Chair of Research in the Department of Dermatology. I dedicate 80% of my time to research and the remaining time taking care of patients with severe inflammatory skin diseases. The central focus of my laboratory is to investigate the cellular and molecular mechanisms that mediate interactions between bacteria and the developing immune system, with a long-term goal of developing new therapeutic approaches based on this knowledge. Work in my lab leverages access to human samples, including human skin and blood, as well as corresponding microbiome samples to dissect the role of host-microbe crosstalk in normal cutaneous immune development and inflammatory skin disease. We also employ a reductionist approach, utilizing sophisticated immunological and microbiological tools in murine models to ask fundamental questions about mechanisms mediating the innate and adaptive immune responses to bacteria in early life.

Publications

Layilin Anchors Regulatory T Cells in Skin.

Journal of immunology (Baltimore, Md. : 1950)

Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

The Journal of Immunology

Michael G Constantinides, Verena M. Link, Samira Tamoutounour, Andrea C. Wong, P. Juliana Perez-Chaparro, Seong-Ji Han, Y. Erin Chen, Kelin Li, Sepideh Farhat, Antonin Weckel, Siddharth R. Krishnamurthy, Ivan Vujkovic-Cvijin, Jonathan L. Linehan, Nicolas Bouladoux, E. Dean Merrill, Sobhan Roy, Daniel J. Cua, Erin J. Adams, Avinash Bhandoola, Tiffany C. Scharschmidt, Jeffrey Aubé, Michael A. Fischbach, Yasmine Belkaid