Publications

Paving the physician-scientist career path: from grassroots gathering to national forum.

Author List

Rhee KY, Emala CW, Gallagher EJ, Rockey DC, Hu PJ, Vyas JM, Cook DP, Scharschmidt TC, Ajijola OA, ASCI Research Pathways Working Group, Williams CS

JCI insight, 2025

Skin microbiome and dermatologic disorders.

Author List

Scharschmidt TC, Segre JA

The Journal of clinical investigation, 2025

The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles.

Author List

Merrill ED, Prudent V, Moghadam P, Rodriguez A, Hurabielle C, Wells EKC, Basso P, Scharschmidt TC, Rosenblum MD, Molofsky AB, Noble SM

bioRxiv : the preprint server for biology, 2025

Epidermal Penetration Increases with Age and May Contribute to Systemic Inflammation.

Author List

Parenteau TR, Celli A, Zhang J, Gonzalez J, Meyer JM, Abegaze B, Piper ML, Elias PM, Abuabara K, Grunfeld C, Man MQ, Scharschmidt TC, Mauro TM

The Journal of investigative dermatology, 2024

Staphylococcus aureus-specific skin resident memory T cells protect against bacteria colonization but exacerbate atopic dermatitis-like flares in mice.

Author List

Braun C, Badiou C, Guironnet-Paquet A, Iwata M, Lenief V, Mosnier A, Beauclair C, Renucci E, Bouschon P, Cuzin R, Briend Y, Patra V, Patot S, Scharschmidt TC, van Wamel W, Lemmens N, Nakajima S, Vandenesh F, Nicolas JF, Lina G, Nosbaum A, Vocanson M

The Journal of allergy and clinical immunology, 2024

Preclinical Atopic Dermatitis Skin in Infants: An Emerging Research Area.

Author List

Paller AS, Scharschmidt TC, Kezic S, Irvine AD

The Journal of investigative dermatology, 2024

218 Staphylococcus aureus-specific skin resident memory T cells protect against bacteria colonization but exacerbate atopic dermatitis-like flares in mice.

Author List

C. Braun, C. Badiou, A. Guironnet-Paquet, M. Iwata, V. Lenief, A. Mosnier, C. Beauclair, E. Renucci, P. Bouchon, R. Cuzin, Y. Briend, V. Patra, S. Patot, T. Scharschmidt, W. van Wamel, N. Lemmens, S. Nakajima, F. Vandenesh, J.-F. Nicolas, G. Lina, A. Nosbaum, M. Vocanson

Journal of Investigative Dermatology, 2023

Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation.

Author List

Dhariwala MO, DeRogatis AM, Okoro JN, Weckel A, Tran VM, Habrylo I, Ojewumi OT, Tammen AE, Leech JM, Merana GR, Carale RO, Barrere-Cain R, Hiam-Galvez KJ, Spitzer MH, Scharschmidt TC

bioRxiv : the preprint server for biology, 2023

LB1714 Increased epidermal penetration in aged skin modulates systemic inflammation.

Author List

A. Celli, M. Man, J. Gonzalez, T. Parenteau, J.M. Meyer, P. Elias, K. Abuabara, C. Grunfeld, T.C. Scharschmidt, T. Mauro

Journal of Investigative Dermatology, 2023

Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.

Author List

Weckel A, Dhariwala MO, Ly K, Tran VM, Ojewumi OT, Riggs JB, Gonzalez JR, Dwyer LR, Okoro JN, Leech JM, Bacino MS, Cho GD, Merana G, Anandasabapathy N, Kumamoto Y, Scharschmidt TC

Immunity, 2023

FLG Deficiency in Mice Alters the Early-Life CD4+ T-Cell Response to Skin Commensal Bacteria.

Author List

Gonzalez JR, Celli A, Weckel A, Dhariwala MO, Merana GR, Ojewumi OT, Okoro J, Dwyer LR, Tran VM, Meyer JM, Mauro TM, Scharschmidt TC

The Journal of investigative dermatology, 2022

544 Commensal induced accumulation of monocyte-derived cells in neonatal skin regulates long-term cutaneous type 17 inflammation.

Author List

M. Dhariwala, J. Okoro, T. Scharschmidt

Journal of Investigative Dermatology, 2022

561 Filaggrin deficiency confers an altered early life T cell response to commensal skin bacteria.

Author List

J. Gonzalez, T. Scharschmidt

Journal of Investigative Dermatology, 2022

The best offense is a good beta-defensin.

Author List

Dhariwala MO, Scharschmidt TC

Immunity, 2022

Intestinal inflammation alters the antigen-specific immune response to a skin commensal.

Author List

Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC

Cell reports, 2022

Early life host-microbe interactions in skin.

Author List

Dwyer LR, Scharschmidt TC

Cell host & microbe, 2022

Skin immunity: dissecting the complex biology of our body's outer barrier.

Author List

Zhang C, Merana GR, Harris-Tryon T, Scharschmidt TC

Mucosal immunology, 2022

Elucidating the Role of the Skin Barrier Protein Filaggrin in the Adaptive Immune Response to Commensals.

Author List

Jeanmarie Gonzalez, Tiffany Scharschmidt

The FASEB Journal, 2021

Colitis alters the antigen-specific response to skin commensal bacteria and predisposes to neutrophilic skin inflammation.

Author List

Geil Ramvielle Merana, Miqdad Dhariwala, Laura Dwyer, Tiffany Scharschmidt

The Journal of Immunology, 2021

002 Colitis alters the antigen-specific response to skin commensal bacteria and predisposes to neutrophilic skin inflammation.

Author List

G.R. Merana, M. Dhariwala, T. Scharschmidt

Journal of Investigative Dermatology, 2021

Intestinal inflammation breaks established immune tolerance to a skin commensal

Author List

Geil R. Merana, Laura R. Dwyer, Miqdad O. Dhariwala, Antonin Weckel, Jeanmarie R. Gonzalez, Joy N. Okoro, Jarish N. Cohen, Courtney M. Tamaki, Jungmin Han, Preston Tasoff, Yasmin Palacios-Calderon, Connie W Y Ha, Susan V. Lynch, Julia A. Segre, Heidi H. Kong, Michael G. Kattah, Averil Ma, Tiffany C. Scharschmidt

Available at: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3863579, 2021

Baby's skin bacteria: first impressions are long-lasting.

Author List

Dhariwala MO, Scharschmidt TC

Trends in immunology, 2021

Layilin Anchors Regulatory T Cells in Skin.

Author List

Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD

Journal of immunology (Baltimore, Md. : 1950), 2021

Regulatory T cells promote innate inflammation after skin barrier breach via TGF-ß activation.

Author List

Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD

Science immunology, 2021

Hair of the mouse: A skin bacteria "cocktail" gets follicles back on their feet.

Author List

Gonzalez JR, Merana GR, Scharschmidt TC

Cell host & microbe, 2021

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Author List

Michael G Constantinides, Verena M. Link, Samira Tamoutounour, Andrea C. Wong, P. Juliana Perez-Chaparro, Seong-Ji Han, Y. Erin Chen, Kelin Li, Sepideh Farhat, Antonin Weckel, Siddharth R. Krishnamurthy, Ivan Vujkovic-Cvijin, Jonathan L. Linehan, Nicolas Bouladoux, E. Dean Merrill, Sobhan Roy, Daniel J. Cua, Erin J. Adams, Avinash Bhandoola, Tiffany C. Scharschmidt, Jeffrey Aubé, Michael A. Fischbach, Yasmine Belkaid

The Journal of Immunology, 2020

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Author List

Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC

Cell reports. Medicine, 2020

Elucidating the Role of the Skin Barrier Protein Filaggrin in the Adaptive Immune Response to Commensals.

Author List

Jeanmarie R. Gonzalez, Tiffany C. Scharschmidt

The FASEB Journal, 2020

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Author List

Miqdad O. Dhariwala, Dhuvarakesh Karthikeyan, Kimberly S. Vasquez, Sepideh Farhat, Antonin Weckel, Keyon Taravati, Elizabeth G. Leitner, Sean Clancy, Mariela Pauli, Merisa L. Piper, Jarish N. Cohen, Judith F. Ashouri, Margaret M. Lowe, Michael D. Rosenblum, Tiffany C. Scharschmidt

, 2020

Atlas of atopic dermatitis.

Author List

Boothby IC, Gonzalez JR, Scharschmidt TC

The Journal of allergy and clinical immunology, 2020

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.

Author List

Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD

JCI insight, 2019

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.

Author List

Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC

Cell host & microbe, 2019

012 Dynamics of alpha beta T cell accumulation in human fetal skin.

Author List

M.O. Dhariwala, K.S. Vasquez, M.L. Pauli, M. Rosenblum, T.C. Scharschmidt

Journal of Investigative Dermatology, 2019

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Author List

Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y

Science (New York, N.Y.), 2019

Fighting staph: Not child’s play.

Author List

Tiffany C. Scharschmidt

Science translational medicine, 2018

925 Neonatal priming shapes preferential capacity for immune tolerance to skin commensal vs. pathogenic bacteria.

Author List

J.M. Leech, K. Chu, E.G. Leitner, J.J. Moon, B.A. Diep, T.C. Scharschmidt

Journal of Investigative Dermatology, 2018

Skin Commensal Antigens: Taking the Road Less Traveled.

Author List

Dhariwala MO, Scharschmidt TC

Trends in immunology, 2018

The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells.

Author List

Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD

Science immunology, 2018

The Microbiome in Atopic Dermatitis.

Author List

Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD

The Journal of allergy and clinical immunology, 2018

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.

Author List

Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W

Microbiome, 2018

Growing good bugs with mom’s milk.

Author List

Tiffany C. Scharschmidt

Science translational medicine, 2017

ILC
regs
: The new kid in class.

Author List

Tiffany C. Scharschmidt

Science translational medicine, 2017

Interferon with antitumor immunity.

Author List

Tiffany C. Scharschmidt

Science translational medicine, 2017

S. aureus
induces IL-36 to start the itch.

Author List

Tiffany C. Scharschmidt

Science translational medicine, 2017

Successful treatment of mucous membrane pemphigoid with bortezomib.

Author List

Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K

JAAD case reports, 2017

Skin Dysbiosis Goes "Off-Leish".

Author List

Scharschmidt TC

Cell host & microbe, 2017

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.

Author List

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD

Cell, 2017

Measuring inflammation in IBD with an OSM-ostat.

Author List

Scharschmidt TC

Science translational medicine, 2017

A vitamin to D-crease sunburn.

Author List

Scharschmidt TC

Science translational medicine, 2017

When TLRs fail, IgG has your back.

Author List

Scharschmidt TC

Science translational medicine, 2017

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.

Author List

Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD

Cell host & microbe, 2017

Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything.

Author List

Scharschmidt TC

Dermatologic clinics, 2017

014 Commensal microbes augment expression of the hair follicle chemokine Ccl20 to facilitate accumulation of Tregs in neonatal skin.

Author List

T.C. Scharschmidt, K.S. Vasquez, M.L. Pauli, H. Truong, J.L. Sonnenburg, S.E. Millar, M.D. Rosenblum

Journal of Investigative Dermatology, 2016

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.

Author List

Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD

Journal of immunology (Baltimore, Md. : 1950), 2016

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.

Author List

Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD

Immunity, 2015

Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated.

Author List

Lin TK, Man MQ, Santiago JL, Scharschmidt TC, Hupe M, Martin-Ezquerra G, Youm JK, Zhai Y, Trullas C, Feingold KR, Elias PM

The Journal of investigative dermatology, 2014

What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome.

Author List

Scharschmidt TC, Fischbach MA

Drug discovery today. Disease mechanisms, 2013

Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature.

Author List

Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K

JAMA dermatology, 2013

Neurogenic rosacea: a distinct clinical subtype requiring a modified approach to treatment.

Author List

Scharschmidt TC, Yost JM, Truong SV, Steinhoff M, Wang KC, Berger TG

Archives of dermatology, 2011

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.

Author List

Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM

The Journal of allergy and clinical immunology, 2009

Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota.

Author List

Scharschmidt TC, List K, Grice EA, Szabo R

The Journal of investigative dermatology, 2009

Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

Author List

Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM

The Journal of investigative dermatology, 2009

Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis.

Author List

Gunathilake R, Schmuth M, Scharschmidt TC, Gruber R, Grabher D, Leslie KS, Maurer TA, Mauro TM, Elias PM

The Journal of investigative dermatology, 2009

Modeling atopic dermatitis with increasingly complex mouse models.

Author List

Scharschmidt TC, Segre JA

The Journal of investigative dermatology, 2008

Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.

Author List

List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH

The Journal of biological chemistry, 2007

Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens.

Author List

An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC

The Journal of biological chemistry, 2001