Publications

218 Staphylococcus aureus-specific skin resident memory T cells protect against bacteria colonization but exacerbate atopic dermatitis-like flares in mice.

C. Braun, C. Badiou, A. Guironnet-Paquet, M. Iwata, V. Lenief, A. Mosnier, C. Beauclair, E. Renucci, P. Bouchon, R. Cuzin, Y. Briend, V. Patra, S. Patot, T. Scharschmidt, W. van Wamel, N. Lemmens, S. Nakajima, F. Vandenesh, J.-F. Nicolas, G. Lina, A. Nosbaum, M. Vocanson
Journal of Investigative Dermatology, 2023

Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation.

Dhariwala MO, DeRogatis AM, Okoro JN, Weckel A, Tran VM, Habrylo I, Ojewumi OT, Tammen AE, Leech JM, Merana GR, Carale RO, Barrere-Cain R, Hiam-Galvez KJ, Spitzer MH, Scharschmidt TC
bioRxiv : the preprint server for biology, 2023

LB1714 Increased epidermal penetration in aged skin modulates systemic inflammation.

A. Celli, M. Man, J. Gonzalez, T. Parenteau, J.M. Meyer, P. Elias, K. Abuabara, C. Grunfeld, T.C. Scharschmidt, T. Mauro
Journal of Investigative Dermatology, 2023

Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.

Weckel A, Dhariwala MO, Ly K, Tran VM, Ojewumi OT, Riggs JB, Gonzalez JR, Dwyer LR, Okoro JN, Leech JM, Bacino MS, Cho GD, Merana G, Anandasabapathy N, Kumamoto Y, Scharschmidt TC
Immunity, 2023

FLG Deficiency in Mice Alters the Early-Life CD4+ T-Cell Response to Skin Commensal Bacteria.

Gonzalez JR, Celli A, Weckel A, Dhariwala MO, Merana GR, Ojewumi OT, Okoro J, Dwyer LR, Tran VM, Meyer JM, Mauro TM, Scharschmidt TC
The Journal of investigative dermatology, 2022

561 Filaggrin deficiency confers an altered early life T cell response to commensal skin bacteria.

J. Gonzalez, T. Scharschmidt
Journal of Investigative Dermatology, 2022

The best offense is a good beta-defensin.

Dhariwala MO, Scharschmidt TC
Immunity, 2022

Intestinal inflammation alters the antigen-specific immune response to a skin commensal.

Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC
Cell reports, 2022

Early life host-microbe interactions in skin.

Dwyer LR, Scharschmidt TC
Cell host & microbe, 2022

Skin immunity: dissecting the complex biology of our body's outer barrier.

Zhang C, Merana GR, Harris-Tryon T, Scharschmidt TC
Mucosal immunology, 2022

Colitis alters the antigen-specific response to skin commensal bacteria and predisposes to neutrophilic skin inflammation.

Geil Ramvielle Merana, Miqdad Dhariwala, Laura Dwyer, Tiffany Scharschmidt
The Journal of Immunology, 2021

002 Colitis alters the antigen-specific response to skin commensal bacteria and predisposes to neutrophilic skin inflammation.

G.R. Merana, M. Dhariwala, T. Scharschmidt
Journal of Investigative Dermatology, 2021

Intestinal inflammation breaks established immune tolerance to a skin commensal

Geil R. Merana, Laura R. Dwyer, Miqdad O. Dhariwala, Antonin Weckel, Jeanmarie R. Gonzalez, Joy N. Okoro, Jarish N. Cohen, Courtney M. Tamaki, Jungmin Han, Preston Tasoff, Yasmin Palacios-Calderon, Connie W Y Ha, Susan V. Lynch, Julia A. Segre, Heidi H. Kong, Michael G. Kattah, Averil Ma, Tiffany C. Scharschmidt
Available at: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3863579, 2021

Baby's skin bacteria: first impressions are long-lasting.

Dhariwala MO, Scharschmidt TC
Trends in immunology, 2021

Layilin Anchors Regulatory T Cells in Skin.

Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD
Journal of immunology (Baltimore, Md. : 1950), 2021

Regulatory T cells promote innate inflammation after skin barrier breach via TGF-ß activation.

Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD
Science immunology, 2021

Hair of the mouse: A skin bacteria "cocktail" gets follicles back on their feet.

Gonzalez JR, Merana GR, Scharschmidt TC
Cell host & microbe, 2021

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Michael G Constantinides, Verena M. Link, Samira Tamoutounour, Andrea C. Wong, P. Juliana Perez-Chaparro, Seong-Ji Han, Y. Erin Chen, Kelin Li, Sepideh Farhat, Antonin Weckel, Siddharth R. Krishnamurthy, Ivan Vujkovic-Cvijin, Jonathan L. Linehan, Nicolas Bouladoux, E. Dean Merrill, Sobhan Roy, Daniel J. Cua, Erin J. Adams, Avinash Bhandoola, Tiffany C. Scharschmidt, Jeffrey Aubé, Michael A. Fischbach, Yasmine Belkaid
The Journal of Immunology, 2020

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC
Cell reports. Medicine, 2020

Elucidating the Role of the Skin Barrier Protein Filaggrin in the Adaptive Immune Response to Commensals.

Jeanmarie R. Gonzalez, Tiffany C. Scharschmidt
The FASEB Journal, 2020

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Miqdad O. Dhariwala, Dhuvarakesh Karthikeyan, Kimberly S. Vasquez, Sepideh Farhat, Antonin Weckel, Keyon Taravati, Elizabeth G. Leitner, Sean Clancy, Mariela Pauli, Merisa L. Piper, Jarish N. Cohen, Judith F. Ashouri, Margaret M. Lowe, Michael D. Rosenblum, Tiffany C. Scharschmidt
, 2020

Atlas of atopic dermatitis.

Boothby IC, Gonzalez JR, Scharschmidt TC
The Journal of allergy and clinical immunology, 2020

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.

Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD
JCI insight, 2019

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.

Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC
Cell host & microbe, 2019

012 Dynamics of alpha beta T cell accumulation in human fetal skin.

M.O. Dhariwala, K.S. Vasquez, M.L. Pauli, M. Rosenblum, T.C. Scharschmidt
Journal of Investigative Dermatology, 2019

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y
Science (New York, N.Y.), 2019

Fighting staph: Not child’s play.

Tiffany C. Scharschmidt
Science translational medicine, 2018

925 Neonatal priming shapes preferential capacity for immune tolerance to skin commensal vs. pathogenic bacteria.

J.M. Leech, K. Chu, E.G. Leitner, J.J. Moon, B.A. Diep, T.C. Scharschmidt
Journal of Investigative Dermatology, 2018

Skin Commensal Antigens: Taking the Road Less Traveled.

Dhariwala MO, Scharschmidt TC
Trends in immunology, 2018

The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells.

Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD
Science immunology, 2018

The Microbiome in Atopic Dermatitis.

Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD
The Journal of allergy and clinical immunology, 2018

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.

Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W
Microbiome, 2018

Growing good bugs with mom’s milk.

Tiffany C. Scharschmidt
Science translational medicine, 2017

ILC regs : The new kid in class.

Tiffany C. Scharschmidt
Science translational medicine, 2017

Interferon with antitumor immunity.

Tiffany C. Scharschmidt
Science translational medicine, 2017

S. aureus induces IL-36 to start the itch.

Tiffany C. Scharschmidt
Science translational medicine, 2017

Successful treatment of mucous membrane pemphigoid with bortezomib.

Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K
JAAD case reports, 2017

Skin Dysbiosis Goes "Off-Leish".

Scharschmidt TC
Cell host & microbe, 2017

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD
Cell, 2017

Measuring inflammation in IBD with an OSM-ostat.

Scharschmidt TC
Science translational medicine, 2017

A vitamin to D-crease sunburn.

Scharschmidt TC
Science translational medicine, 2017

When TLRs fail, IgG has your back.

Scharschmidt TC
Science translational medicine, 2017

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.

Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD
Cell host & microbe, 2017

014 Commensal microbes augment expression of the hair follicle chemokine Ccl20 to facilitate accumulation of Tregs in neonatal skin.

T.C. Scharschmidt, K.S. Vasquez, M.L. Pauli, H. Truong, J.L. Sonnenburg, S.E. Millar, M.D. Rosenblum
Journal of Investigative Dermatology, 2016

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.

Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD
Journal of immunology (Baltimore, Md. : 1950), 2016

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.

Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD
Immunity, 2015

Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated.

Lin TK, Man MQ, Santiago JL, Scharschmidt TC, Hupe M, Martin-Ezquerra G, Youm JK, Zhai Y, Trullas C, Feingold KR, Elias PM
The Journal of investigative dermatology, 2014

What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome.

Scharschmidt TC, Fischbach MA
Drug discovery today. Disease mechanisms, 2013

Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature.

Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K
JAMA dermatology, 2013

Neurogenic rosacea: a distinct clinical subtype requiring a modified approach to treatment.

Scharschmidt TC, Yost JM, Truong SV, Steinhoff M, Wang KC, Berger TG
Archives of dermatology, 2011

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.

Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM
The Journal of allergy and clinical immunology, 2009

Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota.

Scharschmidt TC, List K, Grice EA, Szabo R
The Journal of investigative dermatology, 2009

Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM
The Journal of investigative dermatology, 2009

Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis.

Gunathilake R, Schmuth M, Scharschmidt TC, Gruber R, Grabher D, Leslie KS, Maurer TA, Mauro TM, Elias PM
The Journal of investigative dermatology, 2009

Modeling atopic dermatitis with increasingly complex mouse models.

Scharschmidt TC, Segre JA
The Journal of investigative dermatology, 2008

Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.

List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH
The Journal of biological chemistry, 2007

Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens.

An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC
The Journal of biological chemistry, 2001