Tiffany Scharschmidt, MD

Principal Investigator, Associate Professor
Department of Dermatology

I am a dermatologist, microbiologist, and immunologist and currently serve as an Associate Professor of Dermatology. I dedicate 80% of my time to research and the remaining time taking care of patients with severe inflammatory skin diseases. The central focus of my laboratory is to investigate the cellular and molecular mechanisms that mediate interactions between bacteria and the developing immune system, with a long-term goal of developing new therapeutic approaches based on this knowledge. Work in my lab leverages access to human samples, including human skin and blood, as well as corresponding microbiome samples to dissect the role of host-microbe crosstalk in normal cutaneous immune development and inflammatory skin disease. We also employ a reductionist approach, utilizing sophisticated immunological and microbiological tools in murine models to ask fundamental questions about mechanisms mediating the innate and adaptive immune responses to bacteria in early life.

Publications: 

Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation.

bioRxiv : the preprint server for biology

Dhariwala MO, DeRogatis AM, Okoro JN, Weckel A, Tran VM, Habrylo I, Ojewumi OT, Tammen AE, Leech JM, Merana GR, Carale RO, Barrere-Cain R, Hiam-Galvez KJ, Spitzer MH, Scharschmidt TC

LB1714 Increased epidermal penetration in aged skin modulates systemic inflammation.

Journal of Investigative Dermatology

A. Celli, M. Man, J. Gonzalez, T. Parenteau, J.M. Meyer, P. Elias, K. Abuabara, C. Grunfeld, T.C. Scharschmidt, T. Mauro

Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.

Immunity

Weckel A, Dhariwala MO, Ly K, Tran VM, Ojewumi OT, Riggs JB, Gonzalez JR, Dwyer LR, Okoro JN, Leech JM, Bacino MS, Cho GD, Merana G, Anandasabapathy N, Kumamoto Y, Scharschmidt TC

FLG Deficiency in Mice Alters the Early-Life CD4+ T-Cell Response to Skin Commensal Bacteria.

The Journal of investigative dermatology

Gonzalez JR, Celli A, Weckel A, Dhariwala MO, Merana GR, Ojewumi OT, Okoro J, Dwyer LR, Tran VM, Meyer JM, Mauro TM, Scharschmidt TC

The best offense is a good beta-defensin.

Immunity

Dhariwala MO, Scharschmidt TC

561 Filaggrin deficiency confers an altered early life T cell response to commensal skin bacteria.

Journal of Investigative Dermatology

J. Gonzalez, T. Scharschmidt

Intestinal inflammation alters the antigen-specific immune response to a skin commensal.

Cell reports

Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC

Early life host-microbe interactions in skin.

Cell host & microbe

Dwyer LR, Scharschmidt TC

Skin immunity: dissecting the complex biology of our body's outer barrier.

Mucosal immunology

Zhang C, Merana GR, Harris-Tryon T, Scharschmidt TC

Baby's skin bacteria: first impressions are long-lasting.

Trends in immunology

Dhariwala MO, Scharschmidt TC

Layilin Anchors Regulatory T Cells in Skin.

Journal of immunology (Baltimore, Md. : 1950)

Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD

Regulatory T cells promote innate inflammation after skin barrier breach via TGF-ß activation.

Science immunology

Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD

Hair of the mouse: A skin bacteria "cocktail" gets follicles back on their feet.

Cell host & microbe

Gonzalez JR, Merana GR, Scharschmidt TC

Colitis alters the antigen-specific response to skin commensal bacteria and predisposes to neutrophilic skin inflammation.

The Journal of Immunology

Geil Ramvielle Merana, Miqdad Dhariwala, Laura Dwyer, Tiffany Scharschmidt

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Cell reports. Medicine

Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

The Journal of Immunology

Michael G Constantinides, Verena M. Link, Samira Tamoutounour, Andrea C. Wong, P. Juliana Perez-Chaparro, Seong-Ji Han, Y. Erin Chen, Kelin Li, Sepideh Farhat, Antonin Weckel, Siddharth R. Krishnamurthy, Ivan Vujkovic-Cvijin, Jonathan L. Linehan, Nicolas Bouladoux, E. Dean Merrill, Sobhan Roy, Daniel J. Cua, Erin J. Adams, Avinash Bhandoola, Tiffany C. Scharschmidt, Jeffrey Aubé, Michael A. Fischbach, Yasmine Belkaid

Atlas of atopic dermatitis.

The Journal of allergy and clinical immunology

Boothby IC, Gonzalez JR, Scharschmidt TC

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.

JCI insight

Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.

Cell host & microbe

Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Science (New York, N.Y.)

Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y

The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells.

Science immunology

Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD

The Microbiome in Atopic Dermatitis.

The Journal of allergy and clinical immunology

Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.

Microbiome

Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W

Skin Commensal Antigens: Taking the Road Less Traveled.

Trends in immunology

Dhariwala MO, Scharschmidt TC

Fighting staph: Not child’s play.

Science translational medicine

Tiffany C. Scharschmidt

Successful treatment of mucous membrane pemphigoid with bortezomib.

JAAD case reports

Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K

S. aureus induces IL-36 to start the itch.

Science translational medicine

Tiffany C. Scharschmidt

Growing good bugs with mom’s milk.

Science translational medicine

Tiffany C. Scharschmidt

ILC regs : The new kid in class.

Science translational medicine

Tiffany C. Scharschmidt

Interferon with antitumor immunity.

Science translational medicine

Tiffany C. Scharschmidt

Skin Dysbiosis Goes "Off-Leish".

Cell host & microbe

Scharschmidt TC

A vitamin to D-crease sunburn.

Science translational medicine

Scharschmidt TC

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.

Cell

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD

Measuring inflammation in IBD with an OSM-ostat.

Science translational medicine

Scharschmidt TC

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.

Cell host & microbe

Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD

When TLRs fail, IgG has your back.

Science translational medicine

Scharschmidt TC

014 Commensal microbes augment expression of the hair follicle chemokine Ccl20 to facilitate accumulation of Tregs in neonatal skin.

Journal of Investigative Dermatology

T.C. Scharschmidt, K.S. Vasquez, M.L. Pauli, H. Truong, J.L. Sonnenburg, S.E. Millar, M.D. Rosenblum

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.

Immunity

Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD