Tiffany Scharschmidt, MD

Principal Investigator, Associate Professor
Department of Dermatology
Publications: 

Atlas of atopic dermatitis.

The Journal of allergy and clinical immunology

Boothby IC, Gonzalez JR, Scharschmidt TC

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.

JCI insight

Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.

Cell host & microbe

Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Science (New York, N.Y.)

Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y

The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells.

Science immunology

Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD

The Microbiome in Atopic Dermatitis.

The Journal of allergy and clinical immunology

Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.

Microbiome

Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W

Skin Commensal Antigens: Taking the Road Less Traveled.

Trends in immunology

Dhariwala MO, Scharschmidt TC

Fighting staph: Not child’s play.

Science translational medicine

Tiffany C. Scharschmidt

Successful treatment of mucous membrane pemphigoid with bortezomib.

JAAD case reports

Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K

S. aureus induces IL-36 to start the itch.

Science translational medicine

Tiffany C. Scharschmidt

Growing good bugs with mom’s milk.

Science translational medicine

Tiffany C. Scharschmidt

ILC regs : The new kid in class.

Science translational medicine

Tiffany C. Scharschmidt

Interferon with antitumor immunity.

Science translational medicine

Tiffany C. Scharschmidt

Skin Dysbiosis Goes "Off-Leish".

Cell host & microbe

Scharschmidt TC

A vitamin to D-crease sunburn.

Science translational medicine

Scharschmidt TC

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.

Cell

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD

Measuring inflammation in IBD with an OSM-ostat.

Science translational medicine

Scharschmidt TC

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.

Cell host & microbe

Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD

When TLRs fail, IgG has your back.

Science translational medicine

Scharschmidt TC

014 Commensal microbes augment expression of the hair follicle chemokine Ccl20 to facilitate accumulation of Tregs in neonatal skin.

Journal of Investigative Dermatology

T.C. Scharschmidt, K.S. Vasquez, M.L. Pauli, H. Truong, J.L. Sonnenburg, S.E. Millar, M.D. Rosenblum

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.

Immunity

Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD